Biogistry is a privacy-first clinical genetics workbench designed for genetic counselors, clinical geneticists, researchers, and healthcare providers. It unifies NSGC/ACMG 2026 standardized pedigree chart drawing (vertical, radial, horizontal, and crop-net layout engines), Punnett square probability analysis, ISCN 850-band chromosome idiograms, zero-trust patient intake to pedigree, a real-time collaboration engine, free-form clinical report building, custom calculation scripting, EHR sync, and 10+ validated risk models.

Is Biogistry HIPAA compliant for patient genetic data?

Yes. Biogistry processes 100% of data locally on your device using client-side Web Workers. Patient information and pedigree charts never leave your computer or transmit to any external server.

Which genetic inheritance models does Biogistry support?

Biogistry models autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive, and mitochondrial inheritance patterns, incorporating 10+ risk models, Bayesian probability matrices, and reduced penetrance factors.

Can Biogistry sync data with EHR systems and custom databases?

Yes. Biogistry supports data sync with electronic health record (EHR) systems, custom databases, and local encrypted storage formats while maintaining strict client-side privacy.

Biogistry - Browser-Native Genetics Workbench

Browser-Native Genetics Workbench
Built for Modern Healthcare

A browser-native genetics suite for modern clinics. Map clinical pedigrees, run Punnett crosses, and plot chromosome idiograms alongside advanced clinical risk calculation models. Powered by secure client-side local storage for HIPAA compliance, ensuring patient records and clinical analysis remain completely private.

Calculation Engine / Model	Clinical Function & Analysis Description
Claus Model (Breast Cancer Lifetime Risk)	Age-dependent remaining lifetime and 10-year invasive breast cancer risk table evaluation (Claus et al. 1994) with exponential hazard projections.
NCCN 2026 High-Risk Hereditary Cancer Referral Evaluator	Algorithmic decision tree evaluating patient and family pedigree history against NCCN 2026 criteria for HBOC, Lynch syndrome, and high-risk cancer genetic testing referral.
Custom Clinician Scripting & Institutional Risk Engine (Enterprise)	Institution-authorable custom risk engine builder with visual AST graph queries, restricted MathJS calculation sandbox, and copy-on-write model version control.
Wright's Coefficient of Inbreeding (F) Calculator	Pedigree graph traversal calculating individual autozygosity probabilities and consanguinity coefficients from ancestor loops.
Malécot Kinship Coefficient (φ) Matrix Engine	Recurrence matrix computing pair-wise genetic kinship coefficients across complex multi-generational family trees.
Coefficient of Relationship (r) Calculator	Quantitative evaluation of shared allele proportions between any two individuals in the pedigree.
BRCAPRO & Bayesian Peeling Carrier Model	Multi-generational breast/ovarian cancer carrier probability engine compounding BRCA1/2 priors across family trees.
Gail Model (NCI BCRAT Invasive Breast Cancer)	5-year and lifetime invasive breast cancer risk assessment incorporating age at menarche, first live birth, biopsy history, and first-degree relatives.
PREMM5* Lynch Syndrome Multi-Gene Score	5-gene clinical predictive model calculating germline mutation probabilities for MLH1, MSH2, MSH6, PMS2, and EPCAM (*Academic implementation based on Kastrinos et al. JCO 2017; not the licensed DFCI tool).
MMRpro Lynch Syndrome Bayesian Calculator	Bayesian pedigree calculation estimating carrier probabilities for mismatch repair genes and colorectal/endometrial cancer risks.
Chompret Criteria (2015 Revision) TP53 Evaluator	Algorithmic decision engine evaluating Li-Fraumeni Syndrome testing eligibility based on core LFS tumors and onset ages.
PancPRO Familial Pancreatic Cancer Model	Bayesian risk calculator estimating familial pancreatic ductal adenocarcinoma probability and germline mutation risk (BRCA2, PALB2, CDKN2A, ATM).
Prostate Cancer Polygenic & Familial Risk Engine	Age-dependent hazard scaling model assessing prostate cancer risk based on first- and second-degree family history.
BRCAPRO Ovarian Cancer Risk Module	Cumulative lifetime ovarian cancer risk model incorporating BRCA status, tubal ligation/oophorectomy status, and family history.
Hardy-Weinberg Population Carrier Frequency Calculator	Ethnicity-adjusted population carrier frequency calculator and joint carrier probability determination for autosomal recessive panel conditions.
Residual Carrier Risk Post-Negative Testing	Bayesian posterior carrier probability reduction calculation following negative multi-gene panel testing.
Age-Dependent Cumulative Penetrance & Survival Curves	Survival function hazard projections estimating residual lifetime risk for asymptomatic mutation carriers.
Bayesian Pedigree Peeling & Joint Likelihood Engine	Recursive graph likelihood peeling algorithm calculating conditional genotype probabilities across consanguineous pedigree loops.
Punnett Square Mendelian Allele Derivation Engine	Automated derivation of offspring genotypic and phenotypic ratios for monohybrid, dihybrid, and sex-linked crosses.
Automated Mendelian Inheritance Pattern Classifier	Topological graph analysis determining Autosomal Recessive, Autosomal Dominant, X-Linked Recessive, X-Linked Dominant, Y-Linked, and Mitochondrial patterns.

Calculation Engine / Model

Clinical Function & Analysis Description

Claus Model (Breast Cancer Lifetime Risk)

Age-dependent remaining lifetime and 10-year invasive breast cancer risk table evaluation (Claus et al. 1994) with exponential hazard projections.

NCCN 2026 High-Risk Hereditary Cancer Referral Evaluator

Algorithmic decision tree evaluating patient and family pedigree history against NCCN 2026 criteria for HBOC, Lynch syndrome, and high-risk cancer genetic testing referral.

Custom Clinician Scripting & Institutional Risk Engine (Enterprise)

Institution-authorable custom risk engine builder with visual AST graph queries, restricted MathJS calculation sandbox, and copy-on-write model version control.

Wright's Coefficient of Inbreeding (F) Calculator

Pedigree graph traversal calculating individual autozygosity probabilities and consanguinity coefficients from ancestor loops.

Malécot Kinship Coefficient (φ) Matrix Engine

Recurrence matrix computing pair-wise genetic kinship coefficients across complex multi-generational family trees.

Coefficient of Relationship (r) Calculator

Quantitative evaluation of shared allele proportions between any two individuals in the pedigree.

BRCAPRO & Bayesian Peeling Carrier Model

Multi-generational breast/ovarian cancer carrier probability engine compounding BRCA1/2 priors across family trees.

Gail Model (NCI BCRAT Invasive Breast Cancer)

5-year and lifetime invasive breast cancer risk assessment incorporating age at menarche, first live birth, biopsy history, and first-degree relatives.

PREMM5* Lynch Syndrome Multi-Gene Score

5-gene clinical predictive model calculating germline mutation probabilities for MLH1, MSH2, MSH6, PMS2, and EPCAM (*Academic implementation based on Kastrinos et al. JCO 2017; not the licensed DFCI tool).

MMRpro Lynch Syndrome Bayesian Calculator

Bayesian pedigree calculation estimating carrier probabilities for mismatch repair genes and colorectal/endometrial cancer risks.

Chompret Criteria (2015 Revision) TP53 Evaluator

Algorithmic decision engine evaluating Li-Fraumeni Syndrome testing eligibility based on core LFS tumors and onset ages.

PancPRO Familial Pancreatic Cancer Model

Bayesian risk calculator estimating familial pancreatic ductal adenocarcinoma probability and germline mutation risk (BRCA2, PALB2, CDKN2A, ATM).

Prostate Cancer Polygenic & Familial Risk Engine

Age-dependent hazard scaling model assessing prostate cancer risk based on first- and second-degree family history.

BRCAPRO Ovarian Cancer Risk Module

Cumulative lifetime ovarian cancer risk model incorporating BRCA status, tubal ligation/oophorectomy status, and family history.

Hardy-Weinberg Population Carrier Frequency Calculator

Ethnicity-adjusted population carrier frequency calculator and joint carrier probability determination for autosomal recessive panel conditions.

Residual Carrier Risk Post-Negative Testing

Bayesian posterior carrier probability reduction calculation following negative multi-gene panel testing.

Age-Dependent Cumulative Penetrance & Survival Curves

Survival function hazard projections estimating residual lifetime risk for asymptomatic mutation carriers.

Bayesian Pedigree Peeling & Joint Likelihood Engine

Recursive graph likelihood peeling algorithm calculating conditional genotype probabilities across consanguineous pedigree loops.

Punnett Square Mendelian Allele Derivation Engine

Automated derivation of offspring genotypic and phenotypic ratios for monohybrid, dihybrid, and sex-linked crosses.

Automated Mendelian Inheritance Pattern Classifier

Topological graph analysis determining Autosomal Recessive, Autosomal Dominant, X-Linked Recessive, X-Linked Dominant, Y-Linked, and Mitochondrial patterns.

Biogistry Multi-Generational Pedigree Canvas and ACMG Kinship Inspector UI

MODULE 01 · PEDIGREE CANVAS

Multi-Generational Pedigree Canvas & Kinship Inspector

ACMG 2026 Standardized Pedigree Symbols, 4 Graph Layout Engines & Consanguinity Autozygosity Analysis

Biogistry provides a browser-native vector canvas for mapping complex multi-generational clinical pedigrees using standard ACMG 2026 cytogenetic symbols. Geneticists, clinical researchers, and genetic counselors can construct pedigree trees across four distinct layout rendering algorithms: Vertical Standard, Linear Horizontal, Consanguineous Radial, and Crop-Net subgraph focus.

Selecting any individual opens the interactive Node Inspector to evaluate Human Phenotype Ontology (HPO) terms, ClinVar variant links, disease phenotypes, and automated kinship matrices, calculating Wright's Coefficient of Inbreeding (F) and Malécot Kinship (φ) in real-time.

ACMG 2026 Symbols Wright's F Inbreeding 4 Layout Engines HPO & ClinVar Sync

Biogistry Auto-Synchronized Punnett Square Allele Cross Engine UI

MODULE 02 · PUNNETT ENGINE

Auto-Synchronized Punnett Square & Allele Derivation Engine

Zero-Double-Entry Reactive Crosses Derived Directly from Pedigree Intakes

Eliminate repetitive manual data entry across clinical software. Biogistry automatically extracts parent zygosities set on the pedigree canvas to generate interactive Punnett squares in real-time. Clinicians can model monohybrid, dihybrid, and sex-linked Mendelian crosses instantaneously.

The Punnett cross engine computes precise genotypic ratios, phenotypic distribution probabilities, and sex-split carrier likelihood matrices. Any update to parental zygosity or disease status on the pedigree canvas immediately recalculates connected Punnett crosses across the entire workspace.

Mendelian Allele Derivation Sex-Linked Ratios Bi-Directional Sync Reactive Genotype Matrices

Biogistry High-Resolution Chromosome Idiogram Cytogenetic Inspector UI

MODULE 03 · CHROMOSOME IDIOGRAM

ISCN 850-Band Chromosome Idiograms & Locus Inspector

Band-Level Cytogenetic Mapping with Direct ClinGen, OMIM, UCSC & Ensembl API Integration

Inspect human karyotypes at ISCN 850-band resolution with deep cytogenetic zooming past 5Mb. Clinicians can analyze copy number variations (CNVs), evaluate structural chromosomal rearrangements, and pin target gene loci directly onto interactive chromosome maps.

With 1-click live browser connections to authoritative biomedical databases (including ClinGen, OMIM, UCSC Genome Browser, and Ensembl REST APIs), users can query variant classifications and cytoband coordinates without third-party server proxies or middleman tracking.

ISCN 850 Banding GRCh38 Coordinates ClinGen & OMIM Lookup 5Mb Locus Zoom

Biogistry 10+ Clinical Risk Models and Step-by-Step Transparent Math UI

MODULE 04 · RISK CALCULATOR ENGINE

10+ Validated Clinical Risk Engines & Transparent Step-by-Step Math

Auditable Published Equations with Zero Blackbox Issues

Biogistry equips clinicians and researchers with 10+ clinical risk calculation models including Claus Model (BCRAT tables & exponential hazard curves), NCCN 2026 High-Risk Referral Criteria, Gail Model, BRCAPRO, PREMM5* Lynch Syndrome Score, MMRpro, PancPRO, Chompret TP53 Evaluator, and Bayesian Peeling. Every calculator operates with total transparency, allowing users to inspect active equations, conditional likelihood vectors, and exact calculation steps.

By eliminating server-side blackbox algorithms, clinicians can audit the exact mathematical formulas, penetrance curves, and population priors used to derive risk scores. Generated calculations produce auditable clinical summaries and copyable patient narratives with zero hidden variables. (*Note: PREMM5 calculations are academic implementations based on published peer-reviewed algorithms (Kastrinos et al., JCO 2017) and are not the proprietary/licensed DFCI tool).

10+ Clinical Risk Engines Claus Model & NCCN 2026 Gail Model & PREMM5* Zero Blackbox Math

Explore 10+ Clinical Risk Engines →

Biogistry Global Multi-Diagram Synthesis and HIPAA PHI Anonymization UI

MODULE 05 · GLOBAL SYNTHESIS

Global Multi-Diagram Synthesis & HIPAA/GDPR PHI De-Identification

Cross-Worksheet Integrity Validation & One-Click Compliant Anonymization

While individual worksheets handle specialized diagnostics, the Global Analysis Sheet unifies findings across Pedigree, Punnett, and Idiogram engines into a single diagnostic view. It executes automated cross-sheet integrity checks to flag clinical inconsistencies and missing genotype data.

For academic research, clinical trials, and multi-institutional consultations, Biogistry features automated HIPAA and GDPR Protected Health Information (PHI) de-identification. One click replaces patient names and MRN identifiers with secure randomized cryptographic hashes while preserving full pedigree graph topologies.

Unified Global Synthesis Cross-Sheet Integrity Validation HIPAA/GDPR PHI Anonymizer EHR Compliance

Explore Global Synthesis & HIPAA Anonymization →

Biogistry Free-Form Clinical Report Builder and Multi-Format PDF Export UI

MODULE 06 · CLINICAL REPORTS

Free-Form Clinical Report Builder & Multi-Format PDF Export

Custom Consultation Notes with Embedded Dynamic Charts & Vector-Quality PDF Generation

Compose professional medical consultation documentation inside Biogistry without external word processors. The Clinical Report Builder provides a flexible canvas for drafting diagnostic summaries, attaching live pedigree trees, embedding Punnett squares, and uploading device imagery.

Accelerate clinical intake with 5 pre-seeded consultation templates: Diagnostic Summary, Hereditary Cancer Risk, Prenatal Screening, Pediatric Intake, and Cytogenetic Findings. Reports export instantly as vector-quality PDFs or Markdown files ready for direct EHR record attachment.

5 Clinical Templates Dynamic Pedigree Embedding Vector PDF Export EHR Markdown Attachment

Explore Clinical Report Builder →

MODULE 07 · REAL-TIME COLLABORATION

Zero-Knowledge Encrypted Real-Time Collaboration Workbench

End-to-End Encrypted Session Sharing, Live Canvas Cursors and Dynamic Access Roles

Collaborate seamlessly on live pedigree trees without exposing sensitive patient data to cloud servers. Built on WebCrypto AES-256-GCM zero-knowledge client-side encryption and Yjs CRDT synchronization, room keys are generated in browser memory and passed strictly via URL fragments.

Workspaces support up to 10 active collaborators per live session with real-time cursor tracking, canvas selection indicators, and edge awareness pills. Host session creators can invite participants under granular Collaborator or Viewer roles, manage active allowlists, and rotate encryption keys instantly.

AES-256-GCM E2EE Up to 10 Collaborators Collaborator & Viewer Roles Live Cursor Presence

Explore Zero-Knowledge Collaboration →

Biogistry Patient Intake to Pedigree Chart Builder UI

MODULE 08 · PATIENT INTAKE TO PEDIGREE

Patient Intake to Pedigree Builder with Automated Chart Generation

Authoritative Genetics Data Resolved in Your Browser with Zero Manual Drawing

Transform patient family history questionnaires into publication grade pedigree charts in a single click. Patients complete intuitive, step-by-step family history forms prior to their appointment without requiring technical guidance. Biogistry automatically converts received responses into complete pedigree trees, instantly rendering clean, perfectly organized family charts directly in your browser.

Eliminate hours of manual canvas drawing and tedious node arrangement. Spouses, siblings, and multi-generational lineages are automatically structured with flawless spacing and zero overlapping lines. Authoritative genetics data is resolved in your browser so you can focus on patient care, risk evaluation, and clinical consultation.

Automated Form-to-Chart Zero Manual Drawing Clean Family Structure Instant Clinical Intake

Explore Patient Intake Builder →

Biogistry Custom Clinician Scripting and Institutional Risk Engine UI

MODULE 09 · CUSTOM RISK ENGINES

Custom Clinician Scripting & Institutional Risk Engine

Institutional Risk Modeling, Visual Lineage Rules and Real-Time Calculation Engines

Author institution specific risk models, formula decision trees, and familial disease criteria without cloud deployment delays or patient privacy risks. Evaluate multi-generational pedigree logic across maternal and paternal lineages directly in your browser with zero calculation latency.

Maintain institutional versioning with copy on write cloning and full clinical model lifecycle management. Test complex risk logic instantly against live family trees with interactive scope variable autocompletion and auditable transparency.

Zero Cloud Latency Institutional Model Versioning Visual Lineage Rules Custom Formula Engine

Explore Custom Scripting Engine →

pedigree_clinical_embed.svg

<svg viewBox="0 0 618 352" xmlns="http://www.w3.org/2000/svg">
  <defs>
    <style>@import url('https://fonts.googleapis.com/...');</style>
    <linearGradient id="pgCarrier" />
  </defs>
  <g transform="translate(90,276)">
    <!-- Pedigree Canvas Relationships & Nodes -->
    <line x1="243.16" y1="-200" stroke="#64748B" />
    <rect x="217.16" y="-26" stroke="#2563EB" />
    <circle cx="411.16" cy="-200" stroke="#DB2777" />
    <text class="pg">LEGEND: Male / Female</text>
  </g>
</svg>

Universal Vector Embed

Scalable SVG Vector Embeds

Copy crisp, resolution-independent vector diagrams into any paper, portal, or application

Copy raw, high-resolution SVG vector markup with a single click. Paste live pedigree diagrams directly into clinical documentation, research publications, Notion, GitHub, or custom web portals.

Generates self-contained, resolution-independent vector graphics that scale losslessly to any resolution with zero cloud dependencies or external server scripts.

1-Click Code Copy 100% Scalable Vector Works Offline Zero Cloud Dependency Research & EHR Compatible

Browser-Native Genetics WorkbenchBuilt for Modern Healthcare

Experience Biogistry in Action

Pedigree Canvas, 4 Layout Engines & Node Inspector

01 - Pedigree Canvas, 4 Layout Engines & Node Inspector (00:00 - 00:24)

Multi-Generational Charting & Automated Kinship Relationship Matrix

02 - Pedigree Structure Analysis & Bayesian Risk Engine (00:24 - 01:08)

Transparent Clinical Calculators with Auditable Published Equations

03 - Auto-Synchronized Punnett Cross Sheet & Panel (01:09 - 01:46)

Reactive Allele Derivation Derived Directly from Pedigree Intake

04 - High-Resolution Chromosome Idiograms & Cytogenetic Inspector (01:46 - 02:27)

Band-Level Karyotyping & Direct Biomedical Database Lookup

05 - Global Multi-Diagram Synthesis & HIPAA De-Identification (02:28 - 02:42)

Cross-Diagram Diagnostics & Automated PHI Anonymization

06 - Free-Form Clinical Report Builder & Multi-Format PDF Export (02:43 - 03:19)

Customizable Medical Documentation Without External Software

07 - Interoperability, SMART on FHIR, Local BAA Sync & PWA (03:20 - 03:28)

Local-First Privacy Architecture with Enterprise Cloud Connectors

Ready to Experience Biogistry?

Clinical Efficiency

Diagnostic Rigor

Security & Portability

Multi-Generational Pedigree Canvas & Kinship Inspector

ACMG 2026 Standardized Pedigree Symbols, 4 Graph Layout Engines & Consanguinity Autozygosity Analysis

Auto-Synchronized Punnett Square & Allele Derivation Engine

Zero-Double-Entry Reactive Crosses Derived Directly from Pedigree Intakes

ISCN 850-Band Chromosome Idiograms & Locus Inspector

Band-Level Cytogenetic Mapping with Direct ClinGen, OMIM, UCSC & Ensembl API Integration

10+ Validated Clinical Risk Engines & Transparent Step-by-Step Math

Auditable Published Equations with Zero Blackbox Issues

Global Multi-Diagram Synthesis & HIPAA/GDPR PHI De-Identification

Cross-Worksheet Integrity Validation & One-Click Compliant Anonymization

Free-Form Clinical Report Builder & Multi-Format PDF Export

Custom Consultation Notes with Embedded Dynamic Charts & Vector-Quality PDF Generation

Zero-Knowledge Encrypted Real-Time Collaboration Workbench

End-to-End Encrypted Session Sharing, Live Canvas Cursors and Dynamic Access Roles

Patient Intake to Pedigree Builder with Automated Chart Generation

Authoritative Genetics Data Resolved in Your Browser with Zero Manual Drawing

Custom Clinician Scripting & Institutional Risk Engine

Institutional Risk Modeling, Visual Lineage Rules and Real-Time Calculation Engines

Scalable SVG Vector Embeds

Copy crisp, resolution-independent vector diagrams into any paper, portal, or application

Authorized External APIs

Monarch Initiative

ClinVar · NCBI

NLM Clinical Tables

WHO ICD-11 API

Ensembl REST

UCSC cytoBand

Accelerating Intake and Automated Risk Assessment

Clinical Bottleneck

Biogistry Solution

High-Throughput Family Studies and Cytogenetic Mapping

Research Challenge

Biogistry Solution

Interactive Mendelian Crosses and Visual Genetics Learning

Educational Barrier

Biogistry Solution

Private Multi-Generational Family Tree and Trait Mapping

Privacy Concern

Biogistry Solution

Zero-Knowledge Client Architecture and EHR Integration

Compliance & Security Risk

Biogistry Solution

IndexedDB + localStorage

Local Storage Sync Directory

Flexible Cloud Backups

JSON Reminders & Imports

Custom Enterprise, On-Premise & Academic Licensing

Pricing FAQs

Accelerate your pedigree workflows

Browser-Native Genetics Workbench
Built for Modern Healthcare